Mycoplasma Unit

Kimron Veterinary Institute

Our team has developed a long-term expertise in diagnostic, molecular epidemiology and research of pathogenicity factors of mycoplasmas found in animal livestock, pets and wildlife with more precisely focus on ruminant and avian mycoplasmas.

The focal points of our mycoplasma research are the following:

• Molecular epidemiological studies using MLST, NGS data of mycoplasma isolates, isolated from local dairy farms as well as from calves imported to Israel from different European countries.
• Molecular mechanisms of M. bovis antimicrobial resistance.
• Identification of virulence determinants and genes affecting M. bovis virulence.
• Development of in vitro and in vivo model systems to study the pathogenesis of M. bovis disease.

Further readings

Calcutt MJ, Lysnyansky I, Sachse K, Fox LK, Nicholas RAJ, Ayling RD (2018). Gap analysis of Mycoplasma bovis disease, diagnosis and control: An aid to identify future development requirements. Transbound Emerg Dis. 65 Suppl 1:91-109. (https://doi.org/10.1111/tbed.12860)

Nicholas RA, Fox LK, Lysnyansky I (2016). Mycoplasma mastitis in cattle: To cull or not to cull.Vet J. 216:142-7. (https://doi.org/10.1016/j.tvjl.2016.08.001) doi: 10.1016/j.tvjl.2016.08.001.

Amram E, Borovok I, Nachum-Biala Y, Ayling R, Lerner U, Harrus S, Lysnyansky I (2016). High Prevalence of Diverse Insertion Sequences within the rRNA Operons of Mycoplasma bovis. Appl Environ Microbiol. 82(21):6386-6394. (https://doi.org/10.1128/AEM.01628-16)

Lysnyansky I, Ayling RD (2016). Mycoplasma bovis: Mechanisms of Resistance and Trends in Antimicrobial Susceptibility. Front Microbiol. 7:595. (https://doi.org/10.3389/fmicb.2016.00595)

Lysnyansky I, Freed M, Rosales RS, Mikula I, Khateb N, Gerchman I, van Straten M, Levisohn S (2016). An overview of Mycoplasma bovis mastitis in Israel (2004-2014). Vet J. 207:180-183. (https://doi.org/10.1016/j.tvjl.2015.10.057)

Amram E, Mikula I, Schnee C, Ayling RD, Nicholas RA, Rosales RS, Harrus S, Lysnyansky I (2015). 16S rRNA gene mutations associated with decreased susceptibility to tetracycline in Mycoplasma bovis. Antimicrob Agents Chemother. 59(2):796-802. (https://doi.org/10.1128/AAC.03876-14)